Structure-activity relationship of grayanotoxins on the positive inotropic effect in guinea-pig myocardium
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Intracellular Na+ activity and positive inotropic effect of sulmazole in guinea pig ventricular myocardium. Comparison with a cardioactive steroid.
Recent studies suggest that inhibition of Na+,K(+)-ATPase may contribute to the positive inotropic action of the imidazopyridine sulmazole. Therefore, we investigated the effect of sulmazole and its stereoisomers and for comparison the effect of the cardioactive steroid dihydroouabain (DHO) on intracellular Na+ activity by means of Na(+)-sensitive microelectrodes. In the resting papillary muscl...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1979
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)66353-5